FBI探員Eli Kane在調查一宗謀殺案時,意外感染了人造的「伊甸病毒」。其他的感染者在短暫獲得完美體態後便面臨基因崩潰的慘死下場,而他卻獲得了罕見的穩定突變,擁有了超級力量與快速自癒的能力。他與前科學家Sonya、天才駭客Jasper以及實驗體Lena結為同盟,誓言阻止瘋狂的執行長Byron。Byron正透過「免費基因檢測」大肆散播病毒,並研發致命的「亞當毒株」企圖製造超人類大軍。為了拯救世界,Lena犧牲自己提供了完整的病毒基因,讓Sonya得以為全人類調配出終極解藥。
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